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Abstract Heat shock proteins HSPs are thought to play a role in the development of cancer and to modulate tumor response to cytotoxic therapy. In this study, we have examined the expression of hsf and HSP genes in normal human prostate epithelial cells and a range of prostate carcinoma cell lines derived from human tumors. Elevated HSP expression in cancer cell lines appeared to be regulated at the post—messenger ribonucleic acid mRNA levels, as indicated by gene chip microarray studies, which indicated little difference in heat shock factor HSF or HSP mRNA expression between the normal and malignant prostate cell lines. When we compared the expression patterns of constitutive HSP genes between PC-3 prostate carcinoma cells growing as monolayers in vitro and as tumor xenografts growing in nude mice in vivo, we found a marked reduction in expression of a wide spectrum of the HSPs in PC-3 tumors. This decreased HSP expression pattern in tumors may underlie the increased sensitivity to heat shock of PC-3 tumors.
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But subject a newt, and a range of other creatures like it, to the same treatment and, eventually, the missing leg will regenerate. The same is true of other body parts too. But how long can these animals keep up this feat? And does it eventual fail, or are the regenerated parts as good as new? To find out, Panagiotis Tsonis and his colleagues have now done the incredible experiment of removing the lenses from the eyes of the same newts for 19 years in succession, as he explained to Chris Smith
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Print shares Illustrative: A brushfire near Kibbutz Re'im east of the Gaza border, July 25, Fire and Rescue Services Southern District Firefighters battled a number of large blazes on Wednesday as Israelis sought to stay cool during an intense heatwave that set records for highest recorded temperatures in July. Several large fires broke out in the afternoon at the Horshim Forest in central Israel and the Ahihud Forest in the north, as well as at the Churchill Forest near Nazareth Illit. Get The Times of Israel's Daily Edition by email and never miss our top stories Free Sign Up A spokesman for the rescue service said one of the fires near Gaza was sparked by an incendiary balloon.
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