Daryl Davies , director of the Alcohol and Brain Research Laboratory at USC, said alcohol flush reaction is your body telling you to slow down and start hydrating. Alcohol or ethanol is broken down or converted in the liver to acetaldehyde, a highly toxic compound that contributes to the hungover feeling. In most people, acetaldehyde is rapidly transformed to harmless acetate and water. Some people take an H2 blocker before they start drinking to slow the breakdown of alcohol to acetaldehyde in their bloodstream. Some may graduate to higher doses because they begin to gain tolerance or take another pill about four hours later, Davies said.
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They inhibit your histamine release. When your body comes into contact with an allergy trigger, such as pollen, dust mites or pet dander, it produces chemicals called histamines, which are behind most allergy symptoms, some of them mentioned above. The histamine reaction is the method your body uses to tell you that something is wrong. Why are they relevant to Asian flushers?
As you can see it worked well. Is there solid evidence that antacids like Pepcid AC can stop alcohol flush reaction? A lot of the information about the efficacy of Pepcid AC in stopping alcohol flushing is anecdotal. In fact, it is widely spoken about on internet forums as the go-to solution for alcohol flush reaction.